The Owls are now looking to appoint their third manager of the campaign as quickly as possible, as they attempt to force their way out of a relegation battle and surge towards safety. Here's a rundown of Sky Bet's latest front-runners who could become the next Sheffield Wednesday manager.
1. Ryan Lowe - Current odds: 33/1
Current job: Plymouth Argyle. Career win percentage: 43.8% Photo: Dan Mullan
2. Slaven Bilic - Current odds: 33/1
Current job: Unemployed. Last job: West Brom. Career win percentage: 46.4% Photo: Michael Regan
3. Marco Silva - Current odds: 33/1
Current job: Unemployed. Last job: Everton. Career win percentage: 50.2% Photo: Laurence Griffiths
4. Grant McCann - Current odds: 33/1
Current job: Hull City. Career win percentage: 40.1% Photo: George Wood